国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (5): 405-408.

• 综述 • 上一篇    下一篇

卵巢冷冻移植的发展历程及研究现状

范东青，张璨，胡艳秋   

  1. 116044 大连医科大学（范东青，张璨）；苏北人民医院生殖中心（胡艳秋）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-10-25 发布日期:2016-10-25
  • 通讯作者: 胡艳秋

Ovary Cryopreservation and Transplantation

FAN Dong-qing, ZHANG Can, HU Yan-qiu   

  1. Dalian Medical University, Dalian 116044, China(FAN Dong-qing, ZHANG Can); Reproductive Center, Subei People's Hospital, Yangzhou 225001, Jiangsu Province, China(HU Yan-qiu)
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-10-25 Online:2016-10-25
  • Contact: HU Yan-qiu

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摘要： 女性生育力保存的方式包括胚胎冷冻、卵子冷冻及卵巢冷冻移植。胚胎冷冻技术相当成熟，玻璃化冷冻胚胎存活率已达90%以上，卵子冷冻也取得了一定进展，相较于前两种保存生育力的方法，卵巢冷冻移植不仅能够保存生殖功能，也有望保存内分泌功能。目前人类卵巢移植主要包括新鲜或冷冻卵巢组织的原位或异位移植。卵巢移植的影响因素包括冷冻保存过程、移植部位及移植前预处理等。随着器官冷冻技术及显微外科技术的完善，整体卵巢冷冻移植逐渐成为卵巢保存的发展方向。但整体卵巢移植尚处于动物实验阶段，人整体卵巢冷冻保存处于探索阶段，尚无统一的冷冻及解冻程序。综述了卵巢冷冻保存及移植的发展历程及研究现状。

关键词: 卵巢, 低温保存, 冷冻, 移植, 自体

Abstract: The methods of female fertility preservation includes embryo cryopreservation, occyte freezing and ovarian tissue cryopreservation. The embryo freezing technology has been well developed with the survival rate over 90%. The oocyte freezing technology has also yielded progress in recent years. The ovarian tissue cryopreservation and transplantation has a predominance in the preservation of both endocrine function and reproductive function. Currently, human ovarian transplantation mainly consists of the orthotopic and heterotopic transplantation of fresh or cryopreserved ovarian tissue. The factors related to ovarian transplantation include the process of cryopreservation, transplantation site and pretreatment before transplantation, etc. With the increasingly improved technology of organ freezing and microsurgery, cryopreservation and transplantation of whole ovary have been the trend of ovarian preservation. However, the whole ovary transplantation is still at the stage of animal experiments. There are not the standard procedure of cryopreservation and thawing. The research progress of ovarian cryopreservation and transplantation was reviewed.

Key words: Ovary, Cryopreservation, Freezing, Transplantation, autologous