国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2019, Vol. 38 ›› Issue (2): 137-141.

• 综述 • 上一篇    下一篇

复发性流产相关精子因素的研究进展

张馨月，王晖，钱云   

  1. 210011 南京医科大学第二附属医院生殖医学科（张馨月，钱云）；南京医科大学生殖医学国家重点实验室，基础医学院组织胚胎学系（王晖）
  • 收稿日期:2018-10-25 修回日期:2018-12-16 出版日期:2019-03-15 发布日期:2019-03-15

Sperm-Related Factors of Recurrent Spontaneous Abortion

ZHANG Xin-yue，WANG Hui，QIAN Yun   

  1. Clinical Center for Reproductive Medicine，Second Affiliated Hospital of Nanjing Medical University，Nanjing 210011，China（ZHANG Xin-yue，QIAN Yun）；State Key Laboratory of Reproductive Medicine，Department of Histology and Embryology，Nanjing Medical University，Nanjing 211166，China（WANG Hui）
  • Received:2018-10-25 Revised:2018-12-16 Published:2019-03-15 Online:2019-03-15

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摘要： 复发性流产（recurrent spontaneous abortion，RSA）的病因主要包括遗传、解剖、内分泌因素、感染、免疫功能异常、血栓前状态、孕妇的全身性疾病以及环境因素等。临床研究显示，精子质量与胚胎发育潜能相关。从传统精液参数、精子功能参数、精子DNA/染色质完整性三个方面综述男性精子因素与RSA之间的关系，希望为RSA的临床诊治提供一定的借鉴意义。

关键词: 精子, 流产, 习惯性, 精子能动性, DNA碎片率

Abstract: The main risk factors of recurrent spontancous abortion(RSA) include genetic, anatomical and endocrine factors, infection, immune dysfunction, pre-thrombotic state, systemic diseases of pregnant women and environmental factors. Clinical studies have shown that sperm quality is closely related to embryo development potential. The sperm-related factors of RSA, a variety of abnormalities in traditional semen parameters, sperm function parameters and sperm DNA / chromatin integrity, were reviewed, which provides a reference for clinical diagnosis and treatment of RSA.

Key words: Spermatozoa, Abortion, habitual, Sperm motility, DNA Fragmentation

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