国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2019, Vol. 38 ›› Issue (3): 194-196.

• 论著 • 上一篇    下一篇

EMs患者长效GnRHa降调节后人工周期行FET的临床结局

周雪源，闻姬，孔伟，方舟，李艳   

  1. 250001 济南，山东中医药大学第二附属医院生殖医学科（周雪源，闻姬，孔伟，方舟）；菏泽市中医医院（李艳）
  • 收稿日期:2019-01-25 修回日期:2019-04-08 出版日期:2019-05-15 发布日期:2019-05-16
  • 通讯作者: 闻姬，E-mail：wj8197@126.com E-mail:1294933141@qq.com
  • 基金资助:
    国家自然科学基金（81771557）；山东省科技发展计划（2014GSF118064）；山东省医药卫生科技发展计划（2014 WS0165）

Clinical Outcome of the Frozen-Thawed Embryo Transfer Following GnRHa Down-Regulation Protocols in Infertile Women with Endometriosis

ZHOU Xue-yuan，WEN Ji，KONG Wei，FANG Zhou，LI Yan   

  1. Department of Reproductive Medicine, Second Affiliated Hospital, Shandong University of Traditional Chinese Medicine, Jinan 250001, Chinａ（ＺHOU Xue-yuan，WEN Ji，KONG Wei，FANG Zhoｕ）；Heze Hospital of Traditional Chinese Medicine, Heze 274000, Shandong Province, Chinａ（ＬＩ Ｙａｎ）
  • Received:2019-01-25 Revised:2019-04-08 Published:2019-05-15 Online:2019-05-16
  • Contact: WEN Ji，E-mail：wj8197@126.com E-mail:1294933141@qq.com

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摘要： 目的：探讨长效促性腺激素释放激素激动剂（GnRHa）降调节对行冻融胚胎移植（FET）的子宫内膜异位症（EMs）患者临床结局的影响。方法：选择2016年1月—2018年1月于山东中医药大学第二附属医院生殖医学科行FET的EMs患者共计320例，随机分为长效GnRHa降调节后人工周期组（A组，160例）和单纯人工周期组（B组，160例），观察2组患者一般资料、临床指标和妊娠结局。结果：2组患者的一般资料、黄体酮转化日CA125水平、孕酮（P）水平、移植胚胎数、早期流产率比较差异均无统计学意义（P＞0.05）；A组黄体酮转化日雌二醇（E2）水平显著低于B组（P＜0.05)，A组黄体酮转化日子宫内膜厚度、黄体酮转化日A型子宫内膜比例、临床妊娠率、胚胎着床率和活产率均高于B组（P＜0.05）。结论：长效GnRHa降调节后人工周期准备内膜可以改善行FET的EMs患者的临床结局。

关键词: 子宫内膜异位症, 受精, 体外, 胚胎移植, 促性腺素释放激素, 妊娠结局

Abstract: Objective：To investigate the effects of different GnRHa down-regulation protocols on the clinical outcomes of frozen-thawed embryo transfer (FET) in infertile women with endometriosis (EMs). Methods：A total of 320 FET cycles of EMs infertile patients were collected in our hospital from January 2016 to January 2018. The patients were randomly grouped into two groups: 160 cases in the group A were treated with the artificial cycle combined with GnRHa down-regulation，and 160 cases in the group B were treated with artificial cycle. Demographic data, cycle characteristics and clinical outcome were compared between the two groups. Results：There were no significant differences in demographic data, serum CA125 level, progesterone level, the number of embryos transferred and miscarriage rate between the two groups (P＜0.05). Compared with the Group B, the Group A had significantly lower estradiol level (P＜0.05), and higher endometrium thickness, proportion of type A endometrium, clinical pregnancy rate, implantation rate and live birth rate (all P＜0.05). Conclusions: The artificial cycle combined with GnRHa down-regulation protocols is helpful to improve the clinical outcome of FET in those infertile women with EMs.

Key words: Endometriosis, Fertilization in vitro, Embryo transfer, Gonadotropin-releasing hormone, Pregnancy outcome

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