关键词: 内分泌干扰物, 配子发生, 胚胎发育, Wnt信号通路, 邻苯二甲酸酯

Abstract: Phthalates (PAEs) are widely used as additives in food, building materials, medical and other industries. Because PAEs are difficult to form strong covalent bonds, they will continue to leak into the environment and be absorbed during people's daily life. As a large class of environmental endocrine disruptors that disrupt reproductive endocrine, PAEs affect gametes and embryo development strongly. The factors of Wnt family participate in the regulation of tissue differentiation, growth and development via multiple mechanisms such as affecting gene expression and inducing cell proliferation. This paper reviews the biochemical character, endocrine disruption mechanisms and pollution conditions of PAEs, and the related Wnt signaling pathways that may affect gametes and embryo development.

Key words: Endocrine disruptors, Gametogenesis, Embryonic development, Wnt signaling pathway, Phthalates