国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2020, Vol. 39 ›› Issue (1): 18-21.

• 论著 • 上一篇    下一篇

冻融胚胎移植发生生化妊娠的相关因素分析

马志渊，王丽媛，土增荣，田秀珠   

  1. 030001太原，山西医科大学第一临床医学院生殖中心（马志渊）；山西医科大学第一医院生殖中心（王丽媛，土增荣，田秀珠）
  • 收稿日期:2019-07-22 修回日期:2019-10-14 出版日期:2020-01-15 发布日期:2020-01-15
  • 通讯作者: 田秀珠， E-mail：2250143701@ qq.com E-mail:779189011@qq.com

Analysis of Relevant Factors of Biochemical Pregnancy during Freeze-Thaw Embryo Transfer

MA Zhi-yuan，WANG Li-yuan，TU Zeng-rong，TIAN Xiu-zhu   

  1. Reproductive Center，First Clinical Medical College，Shanxi Medical University，Taiyuan 030001，China（MA Zhi-yuan）；Reproductive Center，First Hospital of Shanxi Medical University，Taiyuan 030001，China（WANG Li-yuan，TU Zeng-rong，TIAN Xiu-zhu）
  • Received:2019-07-22 Revised:2019-10-14 Published:2020-01-15 Online:2020-01-15
  • Contact: TIAN Xiu-zhu，E-maiｌ： 2250143701@ qq.com E-mail:779189011@qq.com

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摘要： 目的：探讨辅助生殖技术中行冻融胚胎移植（FET）时发生生化妊娠的相关因素。方法：回顾性分析2012年1月—2016年10月在我院生殖中心行FET助孕治疗发生生化妊娠者120例，同期临床妊娠并成功分娩者110例作为对照组。比较2组一般情况、不孕因素、子宫内膜准备情况、受精方式及胚胎移植等情况，选择有统计学及临床意义的因素行多因素Logistic回归分析。结果：有自然流产史的患者，生化妊娠发生的风险增加（OR=2.182，95%CI：1.058～4.501），差异有统计学意义（P＜0.05）；移植胚胎数目≥2枚者较移植胚胎数＜2枚者，生化妊娠发生的风险降低（OR=0.081，95%CI：0.010～0.674），差异有统计学意义（P＜0.05）；移植至少1枚优质胚胎，生化妊娠发生的风险降低（OR=0.473，95%CI：0.268～0.834），差异有统计学意义（P＜0.05）。结论：既往有自然流产史是生化妊娠的危险因素，移植胚胎数目≥2枚及移植优质胚胎是生化妊娠的保护因素。

关键词: 体外受精, 胚胎移植, 妊娠, 低温保存, Logistic模型

Abstract: Objective：To explore the related factors of biochemical pregnancy during freeze-thaw embryo transfer (FET) in assisted reproductive technology. Methods：A total of 120 cases of biochemical pregnancy undergoing FET treatment in our reproductive center were included in this retrospective study, from January 2012 to October 2016. The control group included 110 cases of clinical pregnancy and successful delivery in the same period. The general situation, infertility factors, endometrial preparation, fertilization methods and embryo transfer were compared between the two groups. The factors with statistical and clinical significance were selected for multivariate logistic regression. Results：In patients with history of spontaneous abortion, the risk of biochemical pregnancy was significantly increased(OR=2.182，95%CI：1.058-4.501, P＜0.05). The risk of biochemical pregnancy in the cases with ≥2 embryos transferred was lower than that in those cases with ＜2 embryos transferred(OR=0.081，95%CI：0.010-0.674, P＜0.05). The risk in the cases with at least one high-quality embryo transferred was also significantly lower(OR=0.473，95%CI：0.268-0.834, P＜0.05). Conclusions：The history of spontaneous abortion is a risk factor of biochemical pregnancy. The number of  ≥2 transferred embryos and the transfer of high-quality embryo are two protective factors of biochemical pregnancy.

Key words: Fertilization in vitro, Embryo transfer, Cryopreservation, Pregnancy, Logistic models