关键词: 糖尿病, 妊娠, 高血压, 妊娠性, 内皮, 血管, 细胞因子类, 肾素-血管紧张素系统

Abstract: Gestational diabetes mellitus (GDM), a particular disease of pregnancy, easily causes a series of adverse pregnancy outcomes, such as parodynia, puerperal infection, ketoacidosis, fetal distress, fetal abnormalities, even dead fetus in uterus. Hypertensive disorders of pregnancy (HDP), including gestational hypertension, preeclampsia (PE), eclampsia, chornic hypertension with superimposed preeclampsia, and pregnancy combined with chornic hypertension, are also main causes of maternal death and perinatal death. The clinical manifestation of HDP is characterized by hypertention, proteinuria and edema following functional lesion of organs. It is necessary for those HDP patients with PE (especially, severe PE) to terminate the pregnancy, in which the adverse outcomes of newborns are introduced. In recent years, many studies showed the correlation between GDM and HDP in the pathological mechanism, such as endothelial dysfunction, dyslipidemia, inflammatory factors, renin-angiotensin-aldosterone system (RAAS) and others. In this article, we reviewed the correlation of pathological mechanism between GDM and HDP.

Key words: Diabetes, gestational, Hypertension, pregnancy-induced, Endothelium, vascular, Cytokines, Renin-angiotensin system