肿瘤免疫疗法在子宫内膜癌中的研究进展

doi:10.12280/gjszjk.20200409

摘要/Abstract

摘要：

肿瘤免疫疗法是通过重新启动并维持机体在肿瘤的发生、发展过程中受损的免疫功能,从而抑制与杀灭肿瘤的一种新型疗法,其具有不良反应小、特异性高、杀瘤谱广、复发率低等优点。子宫内膜癌是女性生殖系统常见的恶性肿瘤之一,发病率日渐上升且趋于年轻化,严重威胁着广大女性的生命健康。目前包括免疫检查点抑制剂、过继免疫细胞疗法（adoptive T cell transfer,ACT）和肿瘤疫苗在内的多种肿瘤免疫疗法已用于子宫内膜癌的临床试验与临床应用,且取得重大进展,但其在临床的广泛应用仍受如低应答率及耐药性等问题的阻碍,寻找高效的肿瘤免疫疗法对子宫内膜癌的治疗具有重要意义。现就肿瘤免疫疗法在子宫内膜癌方向的研究进展进行综述,旨在为子宫内膜癌的治疗提供新的思路。

关键词: 免疫疗法, 肿瘤, 子宫内膜肿瘤, 治疗, 疫苗

Abstract:

Tumor immunotherapy is a new therapy to inhibit and kill tumor by restarting and maintaining the immune function damaged in the process of tumor occurrence and development,with the advantages of small adverse reaction, high specificity, wide killing spectrum and low recurrence rate. Endometrial cancer is one of the most common malignant tumors in female reproductive system, and the incidence rate is on the rise and tends to be younger. It is a serious threat to the health of women. At present, many tumor immunotherapies have been used in clinical practice or clinical trial of endometrial cancer, including immunosuppressive checkpoint inhibitors, adoptive T cell therapy (ACT) and tumor vaccine, with the great progress. However, its clinical application is still hindered by the low response rate and drug resistance. It is of great significance to find more efficient tumor immunotherapy for the treatment of endometrial cancer. This article reviews the research progress of tumor immunotherapy in endometrial cancer, in order to provide new ideas for the treatment of endometrial cancer.

Key words: Immunotherapy, Neoplasms, Endometrial neoplasms, Therapy, Vaccines

朱梦迪, 赵国云, 袁晶, 孙宇辉. 肿瘤免疫疗法在子宫内膜癌中的研究进展[J]. 国际生殖健康/计划生育, 2021, 40(2): 172-176.

ZHU Meng-di, ZHAO Guo-yun, YUAN Jing, SUN Yu-hui. Research Progress of Tumor Immunotherapy in Endometrial Cancer[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(2): 172-176.

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