音猬因子信号通路在宫腔粘连纤维化中的研究进展

doi:10.12280/gjszjk.20200592

摘要/Abstract

摘要：

宫腔粘连（intrauterine adhesion,IUA）主要机制包括子宫内膜基底层损伤、子宫内膜修复障碍和纤维化愈合,进而导致女性闭经、月经过少、复发性流产或生育能力低下。子宫内膜纤维化与IUA的发展有关,但目前对IUA的分子机制尚不清楚。音猬因子（Sonic hedgehog,SHH）信号通路在胚胎发育、组织再生和器官发生中起关键作用。越来越多的研究证明SHH信号在各种组织中参与纤维化的发生。SHH信号通路的激活参与了上皮-间质转化（epithelial-mesenchymal transition,EMT）和组织纤维化的诱导,促进成纤维细胞向肌成纤维细胞的转化和纤维化。最近的研究揭示了IUA疾病中SHH信号被激活,表明这种信号的异常调节与子宫内膜纤维化之间存在潜在的联系。就近年SHH信号与IUA纤维化相关研究进展进行综述。

关键词: 组织黏连, 子宫内膜, 猬蛋白质类, 信号传导, 纤维化, 上皮-间质转化, 宫腔粘连

Abstract:

The main mechanisms of intrauterine adhesion (IUA) include endometrial basal layer injury, endometrial repair disorders and fibrotic healing, which leads to amenorrhea, oligomenorrhea, recurrent pregnancy loss or low fertility. Endometrial fibrosis is related to the development of IUA, but the cellular and molecular mechanisms of IUA are still unclear. The sonic hedgehog (SHH) signaling pathway plays a key role in embryonic development, tissue regeneration and organogenesis. In recent years, more and more studies have shown that SHH signaling is involved in the pathogenesis of fibrosis in various tissues. The activated SHH signaling pathway participates in the induction of epithelial-mesenchymal transition (EMT) and tissue fibrosis, and promotes the transformation and fibrosis of fibroblasts into myofibroblasts. SHH signals are activated in IUA diseases, indicating that there is a potential link between the abnormal regulation of this signal and endometrial fibrosis. This review summarizes the research progress of SHH signaling pathway and IUA fibrosis.

Key words: Tissue adhesions, Endometrium, Hedgehog proteins, Signal transduction, Fibrosis, Epithelial-mesenchymal transition, Intrauterine adhesion

王奕翔, 武露明, 王一青, 张学红. 音猬因子信号通路在宫腔粘连纤维化中的研究进展[J]. 国际生殖健康/计划生育, 2021, 40(3): 247-251.

WANG Yi-xiang, WU Lu-ming, WANG Yi-qing, ZHANG Xue-hong. Research Progress of Sonic Hedgehog Signaling Pathway in Intrauterine Adhesion Fibrosis[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(3): 247-251.

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