雄激素在多囊卵巢综合征合并非酒精性脂肪性肝病中的研究进展

doi:10.12280/gjszjk.20210022

摘要/Abstract

摘要：

多囊卵巢综合征（polycystic ovary syndrome,PCOS）是育龄期妇女常见的生殖内分泌紊乱性疾病,且常伴肥胖、胰岛素抵抗（insulin resistance,IR）和脂代谢紊乱等代谢异常。非酒精性脂肪性肝病（non-alcoholic fatty liver disease,NAFLD）是常见的慢性非酒精性肝脏疾病,包括非酒精性单纯性脂肪肝病、非酒精性脂肪性肝炎、肝纤维化、肝硬化及肝细胞癌等一系列肝脏病变。近年来研究发现PCOS中NAFLD的发病率增加,且两者经常共存,越来越多的研究提出PCOS重要的病理生理机制之一高雄激素血症（hyperandrogenemia,HA）在PCOS相关NAFLD发病机制中发挥重要作用。

关键词: 多囊卵巢综合征, 非酒精性脂肪性肝病, 胰岛素抗药性, 细胞因子类, 高雄激素血症, 炎性因子

Abstract:

Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder in women of childbearing age, which is often accompanied by metabolic disorders such as obesity, insulin resistance, lipid metabolism disorder and so on. Non-alcoholic fatty liver disease (NAFLD) is a common chronic non-alcoholic liver disease, including non-alcoholic simple fatty liver disease, non-alcoholic steatohepatitis, liver fibrosis, liver cirrhosis and hepatocellular carcinoma. In recent years, studies have found that the incidence of NAFLD in patients with PCOS increases, and that the two often coexist. More and more studies have proposed that hyperandrogenemia (HA), one of the important pathophysiological factors of PCOS, plays an important role in the pathogenesis of PCOS-related NAFLD.

Key words: Polycystic ovary syndrome, Non-alcoholic fatty liver disease, Insulin resistance, Cytokines, Hyperandrogenemia, Inflammatory factors

彭洋洋, 谢青贞. 雄激素在多囊卵巢综合征合并非酒精性脂肪性肝病中的研究进展[J]. 国际生殖健康/计划生育, 2021, 40(4): 328-333.

PENG Yang-yang, XIE Qing-zhen. Research Progress of Androgen in Polycystic Ovary Syndrome with Non-Alcoholic Fatty Liver Disease[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(4): 328-333.

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