干细胞治疗子宫内膜损伤的研究进展

doi:10.12280/gjszjk.20220179

摘要/Abstract

摘要：

感染因素或宫腔手术操作导致的子宫内膜损伤阻碍胚胎的着床和发育,严重影响妇女的身心健康与生育能力。但目前治疗手段有限且效果欠佳。干细胞具有自我更新和分化潜能,在病变损伤组织的修复过程中发挥重要作用。骨髓间充质干细胞、脐带间充质干细胞、子宫内膜干细胞、脂肪干细胞和人羊膜上皮细胞等多种干细胞治疗子宫内膜损伤已在动物模型和临床研究中开展,并展现出巨大的潜力。干细胞治疗可促进子宫内膜细胞再生,改善子宫内膜厚度和微血管密度,提高受孕率并改善生育结局。干细胞治疗从形态和功能上改善子宫内膜,促进月经和生殖功能的恢复,为治疗子宫内膜损伤提供一种新策略。

关键词: 子宫内膜, 创伤和损伤, 子宫, 组织黏连, 干细胞, 治疗

Abstract:

Endometrial injuries caused by infection or intrauterine hinders the implantation and development of embryos, and seriously affects women′s physical and mental health and their fertility. However, the current treatment approaches are limited and ineffective. Stem cells play an important role in repairing the damaged tissue due to their self-renewal capacity and differentiation potential. The cells used in the stem cells therapy, such as bone mesenchymal stem cells (MSCs), umbilical cord mesenchymal stem cells (UC-MSCs), endometrial stem cells (EnScs), adipose-derived stem cells (ASCs) and human amniotic epithelial cells (hAECs) have been shown the great potential for endometrial injury treatment in the animal models and clinical studies. Stem cell therapy promotes the regeneration of endometrial cells, thereby improving the endometrial thickness and microvessel density, as well as increasing the conception rate and improving the fertility outcome. Stem cell therapy may improve the endometrium morphologically and functionally, and help to restore the menstrual and reproductive functions, providing a new therapeutic strategy for endometrial injuries.

Key words: Endometrium, Wounds and injuries, Uterus, Tissue adhesions, Stem cells, Therapy

沈艳清, 陈煌, 陈烨. 干细胞治疗子宫内膜损伤的研究进展[J]. 国际生殖健康/计划生育, 2022, 41(4): 322-326.

SHEN Yan-qing, CHEN Huang, CHEN Ye. Advances of Stem Cell Therapy for Endometrial Injuries[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(4): 322-326.

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