关键词: 生殖技术, 辅助, 基因组印迹, Beckwith-Wiedemann综合征, DNA甲基化, 序列分析, DNA, 乙酰化作用

Abstract:  Assisted reporductive technology (ART) is an effective treatment of  infertility. However, the safety of reproductive genetics of ART has being concerned. It was reported that the adverse pregnancy outcomes of ART such as low birth weight, spontaneous abortion, fetal malformation, premature delivery, perinatal death were increased. A large number of studies showed that some non-physical interventions on infertility patients, such as the controlling ovarian hyperstimulation, in vitro fertilization and embryo operation, could affect the epigenetics. The imprinting gene play a important role in fetal development during epigenetic modification. ART manipulation is just in the process of epigenetic reprogramming. Therefore, the disorders of imprinting gene will not only impact the fetal development, but also induce developmental abnormalities and many related diseases after birth. This review summarizes the relationship between ART and the disorders of imprinting genes such as Beckwith-Wiedemann syndrome, Prader-Willi syndrome, Angelman syndrome, Silver-Russell syndrome and so on.

Key words: Reproductive techniques, assisted, Genomic imprinting, Beckwith-Wiedemann syndrome, DNA methylation, Sequence analysis, DNA, Acetylation