国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2018, Vol. 37 ›› Issue (1): 66-70.

• 综述 • 上一篇    下一篇

排卵后卵母细胞老化的研究进展

杨继虹，王晖，钱云   

  1. 210011  南京医科大学第二附属医院生殖医学科（杨继虹，钱云）；南京医科大学生殖医学国家重点实验室，南京医科大学基础医学院组织胚胎学系（王晖）
  • 收稿日期:2017-11-15 修回日期:2017-12-25 出版日期:2018-01-15 发布日期:2018-02-02
  • 通讯作者: 钱云，E-mail：qianyun@njmu.edu.cn E-mail:qianyun@njmu.edu.cn

Study Progress of Postovulatory Oocyte Aging

YANG Ji-hong, WANG Hui, QIAN Yun   

  1.  Clinical Center of Reproductive Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China（YANG Ji-hong, QIAN Yun）; State Key Laboraotry of Reproductive Medicine, Department of Histology and Embryology, Basic Medical College, Nanjing Medical University, Nanjing 211166, China（WANG Hui）
  • Received:2017-11-15 Revised:2017-12-25 Published:2018-01-15 Online:2018-02-02
  • Contact: QIAN Yun, E-mail：qianyun@njmu.edu.cn E-mail:qianyun@njmu.edu.cn

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摘要： 卵母细胞老化与许多不良因素有关，氧化应激和线粒体功能紊乱等均致其质量低下，影响进一步发育。作为卵母细胞老化的一种类型，排卵后卵母细胞老化（POA）在体外培养时较为常见，可造成卵母细胞质量下降、胚胎发育不良，导致妊娠率下降和出生缺陷增加。氧化应激是POA过程中的重要触发因素，可激活细胞凋亡通路，影响卵母细胞质量和胚胎发育潜能。现就近年来有关POA的影响因素、与氧化应激的相互作用关系以及使用不同抗氧化剂延缓POA的发生等方面研究进行综述。

关键词: 卵母细胞, 细胞衰老, 氧化性应激, 抗氧化剂, 胚胎发育

Abstract: The oocyte aging is related to many adverse factors, in which oxidative stress and mitochondrial dysfunction lower the quality of oocyte and affect further development. Postovulatory aging (POA), one type of oocyte aging, is more common in the in vitro culture of oocyte, which causes not only dysembryoplasia and poor oocyte quality but also the reduced pregnancy rate and the increased birth defects. Oxidative stress is the essential trigger factor of POA, which may influence the oocyte quality and embryonic developmental potential via the activated apoptosis-related pathways. This paper summarizes the factors of POA, oxidative stre

Key words: Oocytes, Cell aging, Oxidative stress, Antioxidants, Embryonic development