GDF-9和BMP-15在PCOS卵泡发育及胰岛素抵抗中的研究进展

doi:10.12280/gjszjk.20230290

摘要/Abstract

摘要：

生长分化因子-9（growth differentiation factor-9，GDF-9）和骨形态生成蛋白-15（bone morphogenetic protein-15，BMP-15）是转化生长因子-β（transforming growth factor-β，TGF-β）超家族的组成部分，在卵巢中参与颗粒细胞和卵母细胞的增殖分化，影响卵母细胞的发育和质量，调节卵巢功能。GDF-9和BMP-15异常表达，影响卵泡发育和透明带结构，可能是导致多囊卵巢综合征（polycystic ovary syndrome，PCOS）患者不孕的重要环节。BMP-15激活Smad1/5/8信号通路，可能还与PCOS患者的胰岛素抵抗密切相关。但是，血清中GDF-9和BMP-15蛋白难以精确定量，血清GDF-9和BMP-15水平难以作为PCOS特异性诊断与治疗评估的标志。综述GDF-9和BMP-15在卵泡发育中的作用、PCOS患者卵巢GDF-9和BMP-15异常表达对卵泡发育及胰岛素抵抗的影响，探讨GDF-9和BMP-15在PCOS诊治中的潜在应用价值。

关键词: 生长分化因子9, 骨形态发生蛋白质15, 多囊卵巢综合征, 卵母细胞, 转化生长因子β

Abstract:

Growth differentiation factor-9 (GDF-9) and bone morphogenetic protein-15 (BMP-15) are two members of the transforming growth factor-β (TGF-β) superfamily, which participate in the proliferation and differentiation of granulosa cells and oocytes in the ovary. The GDF-9 and BMP-15 secreted by oocyte affect the development and quality of oocytes, and regulate ovarian function, by the interaction between oocyte and cumulus cells. The abnormal expressions of GDF-9 and BMP-15 affect follicular development and zona pellucida structure, which may be an important link leading to infertility in women with polycystic ovary syndrome (PCOS). BMP-15 activates the Smad1/5/8 signaling pathway, which is closely related to insulin resistance (IR) in PCOS patients. However, the precise quantification of serum GDF-9 and BMP-15 levels is difficult, and the levels of serum GDF-9 and BMP-15 are difficult to be used as specific markers for the diagnosis and treatment evaluation of PCOS. This article reviews the roles of GDF-9 and BMP-15 in follicular development, the effects of abnormal expression of GDF-9 and BMP-15 on follicular development and IR in PCOS patients, and discusses the potential application value of GDF-9 and BMP-15 in the diagnosis and treatment of PCOS.

Key words: Growth differentiation factor 9, Bone morphogenetic protein 15, Polycystic ovary syndrome, Oocytes, Transforming growth factor beta

张宇杰, 王文成, 张宁. GDF-9和BMP-15在PCOS卵泡发育及胰岛素抵抗中的研究进展[J]. 国际生殖健康/计划生育杂志, 2023, 42(6): 487-491.

ZHANG Yu-jie, WANG Wen-cheng, ZHANG Ning. Research Progress of GDF-9 and BMP-15 on Follicular Development and Insulin Resistance in PCOS[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(6): 487-491.

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