国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2018, Vol. 37 ›› Issue (5): 401-404.

• 综述 • 上一篇    下一篇

卵巢恶性肿瘤保留生育功能术后不孕患者促排卵治疗的安全性分析

朱跃蒙，李桂玲   

  1. 200090  上海，复旦大学附属妇产科医院中西医结合妇科
  • 收稿日期:2018-07-03 修回日期:2018-09-08 出版日期:2018-09-15 发布日期:2018-09-15
  • 通讯作者: 李桂玲，E-mail: guilingli@fudan.edu.cn E-mail:16211250028@fudan.edu.cn

Safety of Ovulation Induction in Infertile Patients after Fertility-Sapring Surgery for Ovarian Malignant Tumors

ZHU Yue-meng，LI Gui-ling   

  1. Gynecology of Integrated Traditional Chinese and Western Medicine，Obstetrics and Gynecology Hospital of Fudan University，Shanghai 200090，China
  • Received:2018-07-03 Revised:2018-09-08 Published:2018-09-15 Online:2018-09-15
  • Contact: LI Gui-ling, E-mail: guilingli@fudan.edu.cn E-mail:16211250028@fudan.edu.cn

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摘要： 近年来，随着卵巢恶性肿瘤行保留生育功能手术（FSS）的开展，FSS的安全性、远期预后及对生育力的影响也越来越受到关注。FSS治疗早期上皮性卵巢癌不会明确增加其复发率与死亡率，而卵巢恶性生殖细胞肿瘤无论期别早晚均能行FSS。大部分患者FSS术后能自然受孕，但少部分患者需行辅助生殖技术（ART）受孕。而促排卵治疗对卵巢肿瘤的复发是否有影响是医生和患者共同关注的问题。目前认为早期卵巢癌及卵巢交界性肿瘤行FSS是安全可行的，术后辅助化疗对卵巢功能的影响是部分可逆的，但没有充分的证据表明促排卵治疗会增加术后复发率或引起其他恶性肿瘤，仍需进一步研究证实。现就卵巢恶性肿瘤行FSS以及术后促排卵治疗的安全性进行综述。

关键词: 卵巢肿瘤, 生育力, 不孕, 女（雌）性, 排卵诱导, 生殖技术, 辅助

Abstract: With the development of fertility-sparing surgery (FSS) for ovarian malignant tumors in recent years, the safety, long-term prognosis and fertility of FSS have also been paid more and more attention. FSS treatment for early epithelial ovarian cancer does not increase the recurrence rate and mortality. FSS can be performed for malignant germ cell tumors regardless of tumor staging. The pregnancy rate after FSS was different, most of the patients could be able to conceive naturally. However, a few patients after FSS may need the assisted reproductive technology (ART). It is a common concern of both doctors and patients whether ovulation induction can lead to the recurrence of ovarian tumors. The FSS for the ovarian cancer at early stage and the ovarian borderline tumor is safe and feasible, and the effect of adjuvant chemotherapy on ovarian function after operation is reversible. There is no evidence at present that the ovulation induction will increase the postoperative recurrence rate or cause other malignant tumor. We discussed the safety of ovulation induction in those patients after FSS in this review.

Key words: Ovarian neoplasms, Fertility infertility, female, Ovulation induction, Reproductive techniques, assisted