国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (2): 128-131.

• 综述 • 上一篇    下一篇

卵泡发育过程中的Wnt信号通路

周团萍，崔毓桂，千日成   

  1. 210029 南京医科大学第一附属医院生殖医学科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-03-15 发布日期:2016-03-15
  • 通讯作者: 千日成

Wnt Signal Pathway during Folliculogenesis

ZHOU Tuan-ping，CUI Yu-gui，QIAN Ri-cheng   

  1. Clinical Center of Reproductive Medicine，First Affiliated Hospital of Nanjing Medical University，Nanjing 210029，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-03-15 Online:2016-03-15
  • Contact: QIAN Ri-cheng

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摘要： Wnt蛋白与细胞膜上相应受体结合，引起胞质中β-catenin集聚并向核内转移，激活下游相关靶基因的转录。该信号通路是调节卵泡生长发育的一个关键途径。Wnt2影响β-catenin的细胞定位来调节颗粒细胞的增殖；Wnt4是一个多功能因子，在卵泡发育的许多阶段都有表达并通过多种途径来调节卵泡的生长、发育和成熟。受体Fzd1调节卵丘扩展相关因子的表达。β-catenin还参与合成卵巢甾体激素和黄体的生成。该通路受损时，会引起卵巢早衰、诱发颗粒细胞肿瘤、排卵障碍和黄体功能不足等。阐述经典的Wnt信号通路及其在调节卵泡发育过程中的作用及其分子机制。

关键词: 信号传导, 卵泡, 甾类, 激素类, 排卵, 黄体形成

Abstract: The transduction of Wnt signal involves the interaction between Wnt and Fzd as well as cooperation with single-pass co-receptors, which induces the β-catenin translocation to nucleus and the transcription of target genes. This Wnt pathway drives the proliferation of granulosa cells via the intracellular β-catenin translocation. Wnt4 is a pleiotropic player during prenatal and postnatal follicular development, maturation and survival. Fzd1 participates in regulating the expression of those genes involved in cumulus expansion. β-catenin also participates in steroidogenesis and luteogenesis. The maladjustment of β-catenin may lead to premature ovarian failure，granulosa cell tumors and luteal phase defects. In this review, we summarized the classical Wnt/β-catenin pathway and its roles in folliclogenesis.

Key words: Signal transduction, Ovarian follicle, Steroids, Hormones, Ovulation, Luteinization