国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (2): 123-127.

• 综述 • 上一篇    下一篇

生精障碍相关的CDYLs基因家族研究进展

杨骁，陈泰中，费城，黄依哲，夏小雨   

  1. 200025 上海交通大学医学院基础医学系2013级（杨骁，陈泰中，费城，黄依哲），解剖学与组织胚胎学系（夏小雨）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-03-15 发布日期:2016-03-15
  • 通讯作者: 夏小雨

Research Progress of the CDYLs Gene Family Related to Dyszoospermia

YANG Xiao，CHEN Tai-zhong，FEI Cheng，HUANG Yi-zhe，XIA Xiao-yu   

  1. Department of Clinical Medicine，Grade 2013（YANG Xiao，CHEN Tai-zhong，FEI Cheng，HUANG Yi-zhe），Department of Human Anatomy，Histology and Embryology（XIA Xiao-yu），School of Medicine，Shanghai Jiao Tong University，Shanghai 200025，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-03-15 Online:2016-03-15
  • Contact: XIA Xiao-yu

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摘要： CDY（chromodomain protein，Y-linked）基因位于Y染色体AZF区段，是Y染色体微缺失所导致的生精障碍的候选基因之一。CDY基因起源于常染色体CDYLs（CDY-like）基因mRNA的反转录转座。在进化过程中，CDYLs基因家族通过增加新的外显子从而获得蛋白功能的多样性。CDYLs/CDY蛋白包含2个重要的结构域：氨基端的chromo结构域可结合甲基化的组蛋白，主要参与基因沉默的过程；羧基端的crotonase结构域可能参与组蛋白乙酰化的催化，可能在精子发生中发挥重要作用。综述CDYLs/CDY基因的进化、功能及其临床意义。

关键词: 不育, 男（雄）性, 精子, Y染色体, 性染色体畸变, 生精障碍, CDY基因, CDYLs基因

Abstract: As located in AZF region of Y chromosome, CDY (chromodomain protein，Y-linked) gene has been regarded as one of the candidates of Y chromosome microdeletion related to dyszoospermia. Actually, CDY gene originated from the reverse transcription and transposition of autosomal CDYLs (CDY-like) mRNA. During the evolution, autosomal CDYLs acquired the diversity of protein function by acquisition of new exons. The function of CDYLs/CDY protein closely depends on its two domains, the chromo domain mediating the gene silence process by binding to the methylated histones and the crotonase domain which might be involved in spermatogenesis via its histone acetylase activity. Herein, the research progress about the CDYLs/CDY gene family was reviewed.

Key words: Infertility, male, Spermatozoa, Y chromosome, Sex chromosome aberrations, Dyszoospermia, CDY gene, CDYLs gene