国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2014, Vol. 33 ›› Issue (5): 379-383.

• 综述 • 上一篇    下一篇

卵母细胞及其胚胎发育潜能相关的生物标记物

邵丽，崔毓桂，千日成   

  1. 210029 南京医科大学第一附属医院生殖医学中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-09-15 发布日期:2014-09-15
  • 通讯作者: 崔毓桂

Non-invasive Biomarkers of Oocyte and Embryo Developmental Competence

SHAO Li，CUI Yu-gui，QIAN Ri-cheng   

  1. Center of Reproductive Medicine，the First Affiliated Hospital of Nanjing Medical University，Nanjing 210029，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-09-15 Online:2014-09-15
  • Contact: CUI Yu-gui

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摘要： 卵母细胞发育潜能是在卵泡发育过程中逐步获得的，卵丘细胞（CCs）与卵母细胞紧密接触，卵泡液（FF）为卵母细胞提供良好的微环境。因此，CCs功能及FF成分组成可以反映卵母细胞的发育潜能。CCs为卵母细胞提供代谢所需的营养物质如丙酮酸、丙氨酸、胆固醇等，并在卵母细胞的成熟、排卵、受精过程中发挥重要的作用。FF作为卵巢体壁细胞与血浆之间的媒介，其内的代谢相关分子、激素类分子、活性氧分子及一些细胞因子与卵母细胞的成熟及发育潜能密切相关。综述与卵母细胞及其胚胎发育潜能相关的生物标记物，主要是CCs、FF中的相关因子，两者结合为胚胎学家选择最佳的卵子提供参考。

关键词: 卵母细胞, 生物学标记, 卵丘细胞, 卵泡液, 胚胎发育

Abstract: The developmental competence of oocyte is gradually accumulated through folliculogenesis，during which the tight communication between cumulus cells （CCs） and oocyte is established while follicle fulid（FF） maintains an optimal micro-environment for oocyte maturation. So，it is generally accepted that oocyte competence can be evaluated through biological functions of CCs and molecular components of FF within the ovarian follicle. CCs play an important role by providing metabolic nutrients for the oocyte such as pyruvic，alanine，cholesterol and so on，meanwhile CCs are involved in oocyte maturation，ovulation as well as fertilization process. Metabolic factors，hormones，reactive oxygen species and some cytokines in FF are closely linked to oocyte growth. Herein we reviewed the biomarkers of oocyte quality and embryo developmental competence in CCs and FF.

Key words: Oocytes, Biological markers, Cumulus cells, Follicular fluid, Embryonic development