国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2010, Vol. 29 ›› Issue (4): 292-294.

• 综述 • 上一篇    下一篇

抗苗勒管激素与多囊卵巢综合征

汪慧,魏兆莲   

  1. 230022 合肥，安徽医科大学第一附属医院生殖医学 中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-07-15 发布日期:2010-07-15

The Anti-Mullerian Hormone and Polycystic Ovary Syndrome

WANG Hui, WEI Zhao-lian.   

  1. Reproductive Medicine Center, the First Affiliated Hospital, Anhui Medical University, Hefei 230022, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-07-15 Online:2010-07-15

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摘要： 多囊卵巢综合征（PCOS）是一种代谢异常内分泌紊乱的临床综合征。目前认为，卵泡的生
长发育异常可能是引起PCOS 临床代谢内分泌改变的病理生理基础。抗苗勒管激素（anti鄄m俟llerian
hormone, AMH）, 是转化生长因子β（TGF鄄β)超家族成员之一，在卵巢生长卵泡的颗粒细胞中表达，调控
卵泡的生长和发育，在正常卵泡的始基募集和周期募集中起重要作用。AMH 异常可导致内在的卵泡生长
发育异常及卵巢颗粒细胞分泌异常。PCOS 患者AMH 的异常增加可引起卵泡生长发育异常和排卵障碍。
研究AMH 可为探讨PCOS 发病机制提供新的理论基础，并为临床PCOS 诊断和治疗提供新途径和方法。

关键词: 多囊卵巢综合征, 抗苗勒管激素, 颗粒细胞, 卵泡

Abstract: Polycystic ovary syndrome（PCOS）is a clinical syndrome with metabolic abnormity and
endocrine disorder. At present the abnormal follicular growth and development, which cause the clinical
metabolic and endocrine change of PCOS, was considered as the pathophysiologic basis. Anti-Mullerian
hormone（AMH）, also known as Mullerian inhibiting substance（MIS）and belongs to transforming growth
factors-β（TGF-β）superfamily, is expressed in the growth of follicles of ovarian granulosa cells and regulates
the growth and development of follicles. AMH plays an important role in the initial recruitment and periodic
recruitment of normal follicles. A number of studies have shown that the abnormal inherent growth and
development of follicles in ovarian granulosa cells might be related to abnormal secretion of AMH, and in
PCOS patients the abnormal increase of AMH might cause abnormal growth of follicles and ovulation disorder.
The study on AMH may provide a new theoretical foundation for the pathogenesis of PCOS, as well as offer a
new pathway for clinical diagnosis and treatment of PCOS.

Key words: Polycystic ovary syndrome, Anti－Mullerian hormone, Granulosa cell, Follicles