国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2013, Vol. 32 ›› Issue (1): 55-58.

• 综述 • 上一篇    下一篇

哺乳动物血睾屏障相关细胞连接及连接蛋白的研究进展

薛 珂, 丁之德   

  1. 200025 上海交通大学医学院人体组织胚胎学教研室
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-01-15 发布日期:2013-01-15
  • 通讯作者: 丁之德

The Cellular Junctions and Junctional Proteins Related to Mammalian Blood-Testis Barrier

XUE Ke，DING Zhi-de   

  1. Department of Human Histology and Embryology，School of Medicine，Shanghai Jiao Tong University，Shanghai 200025，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-01-15 Online:2013-01-15
  • Contact: DING Zhi-de

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摘要： 在雄性哺乳动物的睾丸中，紧密连接是血睾屏障中的主要结构，为相邻Sertoli细胞之间的一种联系，并与基部外胞质特殊结构和细胞桥粒连接共同存在。血睾屏障在生理上将生精上皮分为两个腔室：基底小室和近腔小室。基底小室内主要有精原细胞和早期精母细胞，而近腔小室有精子发生过程中各个阶段的生精细胞。前细线期精母细胞为了能够进入近腔小室必须穿过血睾屏障，该过程涉及多种分子以及相关的信号传导通路。分析目前与血睾屏障相关的细胞连接及连接蛋白的研究结果，进一步探讨这些细胞连接及连接蛋白对前细线期精母细胞穿越血睾屏障过程的作用。

关键词: 血睾屏障, 塞尔托利细胞, 紧密连接部, 连接蛋白类, 精子发生

Abstract: In the mammalian testis，tight junction is the primary structure of the blood-testis barrier （BTB） between adjacent Sertoli cells. This structure coexists with the basal ectoplasmic specializations and desmosome-gap junctions. Physically，the BTB divides the seminiferous epithelium into two distinct compartments：a basal compartment where spermatogonia and early spermatocytes are found，and an adluminal compartment where more developing germ cells existed in. In order to enter the adluminal compartment，preleptotene spermatocytes must pass through the BTB，in which several molecules and signalling pathways participate. In this review，we summarized some research results concerning the effect of relevant cellular junctions and junctional proteins of BTB on the penetration of preleptotene spermatocytes.

Key words: Blood-testis barrier, Sertoli cells, Tight junctions, Connexins, Spermatogenesis