Research Progress on the Effect of Chronic Endometritis on Fertility

doi:10.12280/gjszjk.20200510

Abstract

Abstract:

Chronic endometritis is a high incidence disease in women of childbearing age. The clinical symptoms are not typical, and the diagnostic criteria are not unified. This disease is often ignored clinically. Chronic endometritis reduces the fertility of women of childbearing age, which can lead to the high risk of infertility, embryo implantation failure and lower live birth rate. It is related to unexplained infertility, recurrent abortion and repeated IVF-ET failure, which seriously affects the reproductive health of women of childbearing age. Endometrial microbial infection is the main cause of chronic endometritis. Different patients may have different types of intrauterine microbial infection. The change of intrauterine microbial environment can cause the inflammatory reaction, the changes in the types of immune active cells, the increased secretion of pro-inflammatory cytokines and the abnormal expression of endometrial pregnancy related regulatory factors. These factors and responses can reduce endometrial receptivity, weaken the immune tolerance during pregnancy, interfere with the implantation of fertilized eggs and affect the embryo implantation. The outcomes are the maintenance failure of pregnancy after implantation, abortion, premature rupture of membranes, premature delivery, intrauterine infection and other pregnancy-related diseases. Patients who have been cured by oral antibiotics can get the improved success rate of re-pregnancy and the rate of live births.

Key words: Endometritis, Chronic disease, Fertility, Infertility,female, Abortion, Embryo implantation

YUAN Jing, CHEN Chao, ZHANG Ying. Research Progress on the Effect of Chronic Endometritis on Fertility[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(3): 256-259.

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