Journal of International Reproductive Health/Family Planning ›› 2022, Vol. 41 ›› Issue (4): 308-312.doi: 10.12280/gjszjk.20220115

• Review • Previous Articles     Next Articles

Injury Factors of Vitrification Cryopreservation and Transplantation of Ovarian Cortex

HUANG Shao-feng, NIU Xiang-li, LIN Zhong(), ZHU Xue-hong, BIN Li, LIU Shu-cen   

  1. Guangxi University of Chinese Medicine, Nanning 530200, China (HUANG Shao-feng, LIU Shu-cen); The Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning 530218, China (NIU Xiang-li, LIN Zhong, ZHU Xue-hong, BIN Li)
  • Received:2022-02-28 Published:2022-07-15 Online:2022-07-20
  • Contact: LIN Zhong E-mail:uters@126.com

Abstract:

The cryopreservation and transplantation of ovarian tissue is technically feasible, and the effectiveness is improved with the development of technology. It can be used to preserve female fertility, especially to preserve the fertility of prepubertal women with cancer who will have radiotherapy and chemotherapy. Vitrification is considered to be one of the most promising methods for cryopreservation of ovarian tissue, but its safety and efficacy need to be further verified. Cryogenic injury and transplantation ischemia-reperfusion injury are two problems of further development of cryopreservation and transplantation, in which the difficulty and focus are how to preserve follicles effectively. The existing freezing and transplantation conditions and effects are evaluated from six aspects of cryoprotectant, ovarian tissue size, cryocarrier, antioxidants, promoting angiogensis and hormones, in order to advance the project of female fertility preservation.

Key words: Ovary, Glass, Cryopreservation, Preservation, biological, Tissue transplantation, Reperfusion injury