Bacteroidetes-Related Gut Microbiota in the Pathogenesis of Polycystic Ovary Syndrome: Metabolic Mechanisms and Targeted Interventions

doi:10.12280/gjszjk.20260223

Abstract

Abstract:

In recent years, increasing attention has been paid to the role of gut microbiota in the development and progression of polycystic ovary syndrome (PCOS), among which the altered abundance of Bacteroidetes-related gut microbiota may be related to the clinical characteristics of PCOS. Bacteroidetes-related gut microbiota may hydrolyze primary bile acids via bile salt hydrolase (BSH), thereby downregulating intestinal farnesoid X receptor (FXR) signaling; it may also activate FXR in a bile acid-independent manner through its metabolite agmatine, inhibiting glucagon-like peptide 1 (GLP-1) secretion; furthermore, it may induce insulin resistance via lipopolysaccharide (LPS)-mediated chronic inflammation. In terms of therapeutic interventions, the gut microbiota modulation strategy represented by probiotics/synbiotics has shown potential in improving metabolic parameters in patients with PCOS. However, the precision intervention strategies targeting Bacteroidetes-related gut microbiota remain to be further investigated. Elucidating the Bacteroidetes-PCOS metabolic pathways may provide new targets for the precise treatment of PCOS.

Key words: Polycystic ovary syndrome, Bacteroidetes, Gastrointestinal microbiome, Bile acid metabolism, Farnesoid X receptor, Glucagon-like peptide 1

FAN Yan-tong, LIU Fang, WANG Shuo-rong, ZHAO Shu-ran, WANG Zhi-min, YUAN Yuan. Bacteroidetes-Related Gut Microbiota in the Pathogenesis of Polycystic Ovary Syndrome: Metabolic Mechanisms and Targeted Interventions[J]. Journal of International Reproductive Health/Family Planning, 2026, 45(5): 429-433.

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