Abstract: Embryo implantation requires blastocyst and endometrium develop synchronously. Endometrial receptivity during the window of implantation plays a key role in embryo implantation. Recent research found that many cytokines, enzymes are closely related to endometrial receptivity. Macrophage migration inhibitory factor is recognized as a multifunctional cytokine in immune response regulation. Recent research found that it may affect the expression of integrin and vascular endothelial growth factor. This review elaborates the relationship between MIF and endometrial receptivity in the process of embryo implantation and the relationships between MIF and some cytokines.

Key words: Macrophage migration inhibitory factors, Endometrial receptivity, Window of implantation, Endometrium, Embryo implantation