Abstract: Gestational diabetes mellitus （GDM）is defined as the glucose intolerance at different degree, which is firstly recognised during pregnancy. GDM affects 1%～10% of all pregnancies. It is associated with the increased rates of cesarean section，macrosomia and shoulder dystocia. Its etiology is relatively complex, while phathophysiological feature is insulin resistance. Visfatin, a peptide predominantly expressed in and secreted from visceral adipose with the effects of mimical insulin and inflammatory factor，has a substantial role in the glucose homeostasis. Recent studies indicated that visfatin was one of the adipocytokines which closely related to the incidence of GDM.

Key words: Nicotinamide phosphoribosyltransferase, Diabetes, gestational, Insulin resistance, Tumor necrosis factor-alpha