Abstract: Objective：To compare the expressions of IRS-2，PPAR-γ mRNAs in the granular cells from patients with metabolic syndrome （MS） and normal women，and explore the relation between MS and infertility. Methods：Twenty-seven patients with MS were regarded as group A，13 patients with MS who reached the standards of blood fat and sugar by combination therapy with food，sport and drugs as group B，and 30 women without MS as the control group. Quantitative RT-qPCR was used to detect the expression of IRS-2，PPAR-γ mRNAs in the granular cells. Results：The dose of Gn of the control group was significantly lower than those of group A and Group B. （Endometrial thickness on the day of hCG injection of group A was significantly higher than those of group B and control group.） E2 level on the day of hCG injection of group A was also significantly lower. Total numbers of retrieved oocyte and mature oocyte of group A were significantly lower than those of group B and control group. However，there were not significant differences in the high-quality embryo rates，implantation rates，clinic pregnancy rates，live birth rates and miscarriage rates among three groups（P＞0.05）. There were significant differences in those parameters among three groups （P＜0.01）. Conclusions：The elevated expressions of IRS-2 and PPAR-γ mRNAs could be related with the local insulin resistance，which could play a role in the pathological mechanism of female reproductive disorders.

Key words: Metabolic syndrome X, Receptor, insulin, Peroxisome proliferator-activated receptors, Ovary