Abstract: Objective：To compare the clinical effects of dydrogesterone and levonorgestrel intrauterine system on the prevention of endometrium polyps recurrence after hysteroscopic polypectomy. Methods：It was a retrospective study with 73 cases who treated with two progestin in preventing endometrium polyps recurrence after hysteroscopic resection. Those patients were divided into two groups. 33 cases in the test group were treated with LNG-IUS（Mirena）, and 40 patients in control group with cyclic dydrogesterone. The menstrual quantity, thickness of endometrium, recurrence rate, and adverse reactions were compared. Results：The endometrium thickness and menstrual quantity in both groups were significantly decreased after treatment within 6 months, while two values in the test group after treatment were significantly lower than those in the control group（Ｐ＝０．０００）. The risk of dotted bleeding in the test group was significantly higher than that in the control group at 6 months（Ｐ＝０．０００）, but the difference was not significant between two groups at 12 months（Ｐ＝０．８０９）． The incidence of nausea was lower in the group at any time after treatment. There were 2 cases relapsed in the control group, no one case recurred in the test group. Conclusions：Progestin therapy is safe and effective to prevent polyp recurrence. Compared with dydrogesterone，LNG-IUS can be encouraged with the more convenience, lower rate of recurrence, and lower risk of adverse effects.

Key words: Endometrial neoplasms, Polyps, Hysteroscopy, Intrauterine devices, Levonorgestrel, Recurrence