Abstract: The assisted reproductive technology（ART） as an effective method of infertility treatment is widely used in the world. With increasing ART offsprings，the long-term security of ART gets more attention. Multiple pregnancy is associated with adverse perinatal outcomes. Besides, growing evidence showed that ART singletons had the increased risks of preterm birth （PTB） and low birthweight, and an increased rate of congenital malformations. The mechanism is not yet clear, however the infertility background，ART procedures and ovarian stimulation may be potential cause of adverse perinatal outcomes of ART offsprings. Counseling for genetics, good birth and good care, and the preimplantation genetic screening（PGS） or prenatal diagnosis if necessary should be used to improve perinatal outcomes of ART offsprings. In this review, we discussed the ART security and perinatal outcomes of ART offsprings.

Key words: Reproductive technology, assisted, Pregnancy outcomes, Premature birth, Infant, low birth weight, Congenital abnormalities