Abstract: Objective: To clarify the effect of psychological and physiological factors on IVF/ICSI outcomes by developing a structural equation model. Methods：442 infertility women who met the inclusion criteria were selected randomly as subjects. Psychological questionnaires （STAI, BDI, PSSS and MCMQ） were used to measure psychological status. Data of social demography, basic disease and treatment were also collected. Basic statistical analysis was conducted by SPSS 16.0, and the structural equation model was developed by AMOS20.0. Results：Through the structural equation modeling, we found that the quality of embryos and the psychological states directly influenced the clinical pregnancy outcomes. Age, bFSH, AFC, the number of retrieved oocyte, Gn starting dose, the treatment duration and total dose of Gn indirectly affected the pregnancy outcomes. Conclusions：The crossover effect between psychological and physiological factors were complicated. It is helpful for improving the pregnancy outcomes to remove the negative psychological factors, besides improving biological factors.

Key words: Reproductive techniques, assisted, Pregnancy outcome, Models, psychological, Models, theoretical, Structural equation model