Journal of International Reproductive Health/Family Planning ›› 2015, Vol. 34 ›› Issue (6): 519-523.

• 综述 • Previous Articles    

Poor Response in Controlled Ovarian Hyperstimulation: Diagnosis and Treatment

ZHANG Yang-yang,XU Yang   

  1. Department of Gynecology and Obstetrics,Peking University First Hospital,Beijing 100034,China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-11-15 Online:2015-11-15
  • Contact: XU Yang

Abstract: Poor ovarian response(POR), which means insensitive to gonadotrophin in the controlled ovarian hyperstimulation (COH), can result in fewer retrieved oocytes, higher cycle cancel rate and reduced clinical pregnancy rate. About 9%-24% of women who received COH treatment could have POR, which is one of the most challenging tasks in reproductive medicine. Until now, there is not accordant diagnostic criteria of POR. In 2011, ESHRE (European Society of human Reproction and Embryology) reached the Bologna Criteria: ①Age over or equal to 40 years, or other high-risk factor; ②History of POR (the number of retrieved oocytes in routine COH was less than or equal to 3); ③The lowered ovarian function, such as AFC<5-7 or AMH<0.5-1.1 ng/mL. POR can be diagnosed if there are two in above three criterions. In this paper, we also introduced the treatment progress of POR, such as the adjusting COH, the increasing dose of gonadotrophin in COH, the pretreatment with androgens and oral contraceptive pills, and the adding growth hormone and aspirin.

Key words: Ovulation Induction, Superovulation, Reproductive Techniques, Assisted, Ovulation Detectio, Poor ovarian response