Abstract: Anti-Mullerian hormone (AMH), also known as Mullerian inhibiting hormone (MIS), was first discovered in the male fetus, because it’s inhibiting Mullerian’s development is determined, playing an important role on the male sexual differentiation. Recent studies showed that AMH is widely used in clinical application related to the diagnosis and treatment of diseases concerning the male reproductive disease, mainly in the following five aspects: ① diagnosis whether patients with hermaphroditism have male gonads, the sensitivity of serum AMH is higher than the Y chromosome, being the better markers in assessing the testicular function of adolescent. ② Compared with serum AMH levels, seminal AMH was significantly associated with spermatogenesis, was positively correlated with semen quality, and it is specific marker to identify obstructive and non-obstructive azoospermia. ③Seminal plasma concentrations of Anti-M ullerian hormone predict motile sperm recovery from cryopreserved semen in asthenozoospermic men ④ Seminal anti-Mullerian hormone levels can predict the outcome after recombinant human follicle-stimulating hormone treatment in men with idiopathic infertility. ⑤seminal AMH is the most specific biomarkers to assess male fertility of cancer patients after chemotherapy

Key words: AMH, male, reproductive health