Abstract: Anti-Mullerian hormone (AMH), also named mullerian inhibiting substance (MIS), is a dimeric glycoprotein produced by the granulosa cells of early developing follicles in female and the Sertoli cells in male. Initially, AMH was known as a hormone involved in the sexual differentiation. Recent studies shows that AMH can also be used as a marker for diagnosis and treatment in assisted reproduction, including assessing ovarian reserve, forecasting ovarian response, predicting the fertilization rate and the clinical pregnancy rate in in-vitro fertilization (IVF). Besides, AMH can be used as an assistant marker to evaluate semen quality and the activity of frozen-thawing semen. Otherwise, AMH has been tried in the assistant diagnosis of premature ovarian failure (POF) and polycystic ovary syndrome (PCOS), the differential diagnosis of severe oligoasthenozoospermia and azoospermatism, and the treatment choices of tumor patients of reproductive age.

Key words: Anti-mullerian hormone, Reproductive techniques, assisted, Ovary, Ovarian follicle, Ovulation induction, Infertility, male