Abstract: Objective：To study the factors influencing the success rate of artificial insemination of husband (AIH) in patients with polycystic ovary syndrome (PCOS). Methods: The clinical data of PCOS patients undergoing AIH between January 2013 and June 2017 were collected, including a total of 226 cycles of 150 cases. Those cycles were grouped according to age, body mass index (BMI), the timing of fertilization, storage time before treatment of semen, the number of mature follicles. The clinical pregnancy rate was compared among groups. Results: ①There was no significant difference in the pregnancy rate among three groups of ＜30 years, 30-35 years and 36-38 years (P＞0.05). ②There was significant difference in the pregnancy rate among three groups related to BMI (P＜0.05). The pregnancy rate in the BMI＜24 kg/m2 group was higher than that in the BMI 24-27 kg/m2 group, or that in the BMI ≥28 kg/m2 group (both P＜0.05). The pregnancy rate in the BMI 24-27 kg/m2 group was higher than that in the BMI ≥28 kg/m2 group (but P＞0.05). ③According to the timing of fertilization，the pregnancy rate of the group with two times of IUI before and after ovulation was significantly higher than that of another group with one time of IUI before ovulation (P＜0.05). ④According to the storage time before treatment of semen, the pregnancy rate in the 10-30 minutes group was higher than that in the ＞30 minutes group (P＜0.05). ⑤When there was one mature follicle, the pregnancy rate of the group with the total progressively motile sperm count (TPMC) 10×106～50×106 was significantly higher than that of the group with TPMC ＞50×106 (P＜0.05). When there were two mature follicles, there was no significant difference in the pregnancy rate between the above two groups (P＞0.05). Conclusions: The age has little influence on the pregnancy rate in those PCOS patients aged ＜39 years. PCOS patients with overweight and obese should be asked to lose weight before IUI treatment. The storage time before treatment of semen should be control within 10-30 minutes. TPMC can be properly adjusted according to the number of mature follicles. Two times of IUI can be arranged before and after ovulation with the informed consent, so as to increase the pregnancy rate.

Key words: Polycystic ovary syndrome, Insemination, artificial, homologous, Age factors, Body mass index, Timing of fertilization, Semen, Ovarian follicles, Sperm count