Journal of International Reproductive Health/Family Planning ›› 2019, Vol. 38 ›› Issue (3): 236-239.

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Epithelial-Mesenchymal Transition and the Development, Function and Diseases of Female Reproductive System

WEN Si-xi, SONG Ya-li, LIU Jing, QUAN Song   

  1. Reproductive Medical Center, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  • Received:2019-01-04 Revised:2019-01-31 Published:2019-05-15 Online:2019-05-16
  • Contact: QUAN Song, E-mail: quansong@smu.edu.cn E-mail:quansong@smu.edu.cn

Abstract: Epithelial-mesenchymal transition (EMT) is the process by which epithelial cells undergo morphological transformation into fibroblasts or mesenchymal cells. EMT plays an important role in embryonic development, tissue regeneration, tumor metastasis, and organ fibrosis. With the continuous discovery of EMT in the field of reproduction, EMT has received attention as an important regulatory mechanism for the female reproductive system. In this review, we discusse the importance of EMT in the formation, development and normal function of female reproductive system, and expound the role of EMT in pathological conditions such as endometriosis, intrauterine adhesions and reproductive system malignancies in order to provide new ideas for the research and treatment of female reproductive system.

Key words: Epithelial-mesenchymal transition, Female urogenital diseases, Infertility, female, Endometriosis

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