Abstract: Objective: To evaluate the effect of intrauterine autologous peripheral blood mononuclear cell (PBMC) perfusion on the pregnancy outcomes in patients with repeated implantation failure (RIF). Methods：All of the relevant literatures published in PubMed, Medline (via.OvidSP), Embase, the Cochrane Library, CNKI, WanFang Data, VIP and other major databases were retrieved electronically from their establishment to January 2020. Meta analysis was performed using RevMan 5.3 software. Results：There were 12 articles, including 5 randomized controlled trials and 7 cohort studies, were  enrolled in this Meta analysis, with a total of 1 170 RIF patients (635 received PBMC perfusion and other 535  for controls). The embryo implantation rate (RR=2.24, 95%CI: 1.42-3.54, P＜0.01), clinical pregnancy rate (RR=2.91, 95%CI: 2.21-3.87, P＜0.001) and the live birth rate (RR=2.25, 95%CI: 1.62-3.12, P＜0.001) in patients received PBMC perfusion were higher than those in the control group. However, there was no significant difference in the abortion rate between the two groups (RR=0.48, 95%CI: 0.20-1.17, P＞0.05). Conclusions：Intrauterine infusion of PBMC can improve the embryo implantation rate, clinical pregnancy rate and live birth rate of RIF patients, which is an effective measure for the treatment of RIF.

Key words: Monocytes；, Embryo transfer；, Fertilization in vitro；, Reproductive techniques, assisted；, Recurrent implantation failure；, Peripheral blood mononuclear cells