Abstract:  Reproductive endocrine diseases are a kind of diseases related with reproductive health. The etiology and clinical features of these diseases were highly heterogeneous. MicroRNAs (miRNAs) are a kind of single-stranded small RNAs composed of 19-24 nucleotides. They can promote the degradation of mRNAs or inhibit the translation of proteins by binding to target mRNAs. As a post-transcriptional regulator of gene expression, miRNAs play an important regulatory role in the whole life process. Recently, with the development of transcriptome sequencing, more and more results have identified the important effects of miRNAs on the pathological mechanism of premature ovarian insufficiency (POI), polycystic ovary syndrome (PCOS) and many other reproduction-related diseases. In this paper, we discuss the regulatory mechanism of miRNAs in reproductive diseases and the potential biomarkers.

Key words: MicroRNAs, Premature ovarian insufficiency, Polycystic ovary syndrome;, Ovarian follicle;, Granulosa cells;, Reproductive techniques, assisted