Candidate Genes Related to Polycystic Ovary Syndrome

doi:10.12280/gjszjk.20200465

Abstract

Abstract:

Polycystic ovary syndrome (PCOS) is a common female reproductive endocrine disorder characterized by hyperandrogenemia, oligo/anovulation, polycystic ovary and fertility decline. The exact etiology and pathological mechanism are not clear. More and more studies have showed that genetic factors play an important role in the pathogenesis of PCOS, and that PCOS may be a polygenic genetic disease. The pathogenesis of PCOS is the result of the interaction between some genetic factors and environmental factors. Therefore, it is of great significance to study the susceptibility genes of PCOS so as to explore the pathogenesis and prevention of PCOS. In this paper, we review the research progress of PCOS candidate genes, mainly including those susceptible genes related to androgen biosynthesis, reserve and function, gonadal dysfunction, insulin resistance (IR), obesity and chronic inflammation. This review may provide new ideas for the etiology, pathological mechanism and targeted treatment of PCOS.

Key words: Polycystic ovary syndrome, Genetic association studies, Polymorphism, genetic, Polymorphism,single nucleotide, Polymorphism,restriction fragment length

MA Li-na, MA Hong-li, GAO Jing-shu, WU Xiao-ke. Candidate Genes Related to Polycystic Ovary Syndrome[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(2): 153-156.

Figures/Tables 1

References 30

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