Circular RNA in Pathophysiology of Polycystic Ovary Syndrome

doi:10.12280/gjszjk.20210307

Abstract

Abstract:

Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine diseases in women of childbearing age, and the incidence of PCOS increased year by year. The clinical manifestations of PCOS are highly heterogeneous, leading to different degrees of decline in the life quality of patients. There is growing evidence that PCOS may be a complex polygenetic disease with strong epigenetic and environmental influences. Some studies conducted high-throughput sequencing or gene chip analysis on ovarian tissues and placental tissues of PCOS patients found multiple differentially expressed circRNA, such as hsa_circ_0006877, hsa_circ_0118530. These differentially expressed circRNA may affect oocyte development and reproductive endocrine balance through their involvement in the ovarian granulosa cell proliferation and apoptosis, androgen synthesis and release. This article reviews the role of circRNA in the occurrence and development of PCOS.

Key words: Polycystic ovary syndrome, Androgens, Apoptosis, Granulosa cells, Ovarian follicle, Circular RNA, Follicle development

HUANG Ling-li, FENG Rui-zhi, QIAN Yun. Circular RNA in Pathophysiology of Polycystic Ovary Syndrome[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(6): 509-513.

Figures/Tables 1

References 28

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