The Correlation between Excessive Activation of Primordial Follicles and Diminished Ovarian Reserve

doi:10.12280/gjszjk.20240540

Abstract

Abstract:

Diminished ovarian reserve (DOR), premature ovarian insufficiency, and premature ovarian failure are significant contributors to female infertility. The initial size of the primordial follicle pool, along with its activation and depletion rates, plays a crucial role in determining ovarian reserve function. The excessive activation of dormant primordial follicles can hasten the depletion of ovarian reserve, resulting in DOR. Thus, preventing the excessive activation of primordial follicles is essential for preserving ovarian reserve function. There is a strong link between the excessive activation of primordial follicles and ovarian reserve status, with the underlying mechanisms involving oxidative stress, immune-inflammatory responses and metabolic pathways. DOR not only accelerates the aging process but also heightens the risk of age-related diseases, ultimately diminishing the life quality. In clinical practice, antioxidant medications are commonly used to protect female fertility by preventing the excessive activation of primordial follicles. However, the evidence is still insufficient, regarding the effectiveness of anti-aging drugs in clinical practice. Therefore, it is necessary to investigate furtherly the complex mechanisms of the excessive activation of primordial follicles, so as to develop new approaches and strategies for preventing and treating DOR.

Key words: Ovarian reserve, Oxidative stress, Immunity, Inflammation, Glucose metabolism disorders, Lipid metabolism disorders, Primordial follicle activation, Amino acid metabolism

JIANG Nan, ZHAO Xiao-li, LI Kai-xi, XU Jia-qi, JIA Ying-ying, XIA Tian. The Correlation between Excessive Activation of Primordial Follicles and Diminished Ovarian Reserve[J]. Journal of International Reproductive Health/Family Planning, 2025, 44(2): 132-136.

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