Abstract: Objective：To investigate the anxiety and depression in patients with polycystic ovary syndrome (PCOS) and the related factors, and to analyze the relationship between the anxiety and depression and the change of electroencephalogram function. Methods：A total of 58 patients with PCOS who were treated at gynecological outpatient department of Guang′anmen Hospital of China Academy of Chinese Medical Sciences from December 2016 to March 2017 were enrolled as the PCOS group, and 35 age-matched normal women as the control group. The questionnaire, self rating anxiety scale (SAS), self rating depression scale (SDS), life events scale (LES) and social support scale (SSRS) for all objects, as well as the dyadic regulation scale (DRS) for those married objects (n=38 and 7, respectively), were used in this study. The brain electrical activity mapping (BEAM) was used to evaluate the electroencephalogram function. Results：The scores of SAS and SDS in the PCOS group were significantly increased than that in the control group (P=0.000). Compared with the control group, the PCOS group had significantly higher score of LES (Z=－2.217, P=0.027), specifically the subscores of life negative events and family-related questions (all P＜0.05). However, there were no significant differences between the two groups in the scores of positive events and work-learning problems and social or other problems in negative life events (all P＞0.05), and also no difference in the score of SSRS (P＞0.05). There were no significant difference in the score of DRS in those married objects between the two groups (P＞0.05). The rate of abnormal BEAM were significantl increased in the PCOS group than in the control group (Z=－5.447, P＜0.01). The PCOS group had the increased brand power of slow δ and θ waves (P＜0.05). There were a significant positive correlation between the BEAM and SAS and SDS (rs=0.447, P=0.000; rs=0.318, P=0.002) and a positive correlation between SAS and SDS (r=0.706, P=0.000) in the PCOS group. Conclusions：PCOS patients had obvious anxiety and depression, and the interplay between anxiety and depression. These negative emotions were related to the negative life events coming from their family. The long-term of negative emotions may affect their electroencephalogram function.

Key words: Polycystic ovary syndrome, Manifest anxiety scale, Depression, Brain mapping