Abstract: Polycystic ovary syndrome (PCOS), a common endocrine disorder, is often accompanied by hyperandrogenemia, ovulatory disorder,  insulin resistance and obesity. In recent years, a large number of studies have found that obesity is closely related to PCOS, and that more than 60% of PCOS patients are overweight or obese. The regulation of appetite and energy intake is very important for maintaining energy balance and body weight. The gut-brain axis is a two-way communication system between the gut bacteria and the brain. Gastrointestinal system can be involved in the gut-brain interaction by producing brain-gut peptide, mainly includes the ghrelin, GLP-1, CCK and PYY. In addition, the changes of gut microbial and its interaction with the gut-brain axis may be involved in the pathogenesis of PCOS. This paper focuses on the possible mechanism of the gut-brain axis involved in the pathogenesis of PCOS, and the related and potential treatment methods of PCOS.

Key words: Gut-brain axis, Polycystic ovary syndrome, Obesity, Gut microbial, Gastrointestinal hormones