Abstract: Anti-Mullerian hormone (AMH), a disulfide-linked dimer of two identical subunits of glycoprotein, is secreted by immature testicular Sertoli cell and ovarian granulosa cells, belonging to the transforming growth factor β super-family. One of main physiological functions is regulating the germ cell development. AMH participates in regulating follicular development and growth. AMH has been used to assess ovarian reserve and to predict menopause age. It can be used to detect early ovarian disease and to assess progression and prognosis of disease. In the area of assisted reproductive technology (ART), the application of AMH gets more and more recognition. With the development of analysis technics, AMH test gets more simple and accurate. Compared with other biological indicators, AMH is relatively stable in the different day of menstrual cycle. Now, AMH, as well as its application in ART, has become a hot-topic in recent years. In this paper, we summarized the function of AMH and its clinical application in ovary-related diseases.

Key words: Anti-Mullerian hormone, Ovarian follicle, Ovary, Ovarian diseases, Reproductive techniques, assisted, Menopause