Abstract: The roles of Sirtuins family in reproductive regulation has become a research hotspot in recent years. Sirtuins can regulate spindle assembly and chromosome arrangement during meiosis, improve meiosis of oocyte, promote mitochondrial biosynthesis, regulate energy homeostasis, and improve oocyte and early embryo quality. Sirtuins can protect in vitro the cultured oocyte by increasing antioxidant enzymes. Sirtuins therefore extent female reproductive life by participating in calorie restriction and anti-oxidation. Sirtuins can also inhibit the apoptosis of human granulosa cells, regulate the secretion of reproductive hormones, and provide a good microenvironment for the development of oocytes. In addition, sirtuins play a positive role in the quality and quantity of male sperm. We summarize the effects of sirtuins and the mechanism in reproductive regulation, so as to provide a reference for the future application of Sirtuins agonists in human reproduction.

Key words: Reproduction, Oocytes, Granulosa cell, Spermatozoa, Sirtuins