Mitophagy and Ovarian Function

doi:10.12280/gjszjk.20220558

Abstract

Abstract:

Mitochondria play a crucial role in determining oocyte development ability and ovarian function. Mitophagy is a process that selectively remove the excess or damaged mitochondria. It is associated with the maintenance of mitochondrial homeostasis and cell survival. However, inhibition or overactivation of mitophagy may affect cell function and cell survival. When exposed to adverse environment, oocyte is impaired in the mitochondrial function, inducing excessive mitophagy. Ultimately, the oocyte quality is declined. The mitochondria of the postovulatory aging oocytes are damaged to a certain extent, the application of antioxidants can induce mitophagy in oocytes to remove the damaged mitochondria and improve oocytes development ability. The relationship between oocytes mitophagy and ovarian function, as well as the effects of adverse environmental stimulation and antioxidants on oocyte mitophagy were reviewed in this paper, to provide a theoretical basis for the application of antioxidants to improve oocyte quality in patients with the decreased ovarian reserve.

Key words: Mitophagy, Oocytes, Aging, Ovarian reserve, Antioxidants

YANG Zhi-juan, YAO Ting, HOU Hai-yan. Mitophagy and Ovarian Function[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(3): 240-244.

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