Abstract: The fertility decline caused by oocyte aging and the decreased ovarian reservation is a bottleneck problem in the field of reproduction，Improving ovarian reserve function is an important factor to improve the natural pregnancy rate and ART success rate of infertile women. It has been found that sirtuin 1 (SIRT1) is an important player in regulating the key processes of oogenesis and cellular stress response. SIRT1 can inhibit oocyte senescence by regulating oocyte number, improving oocyte quality, inhibiting oxidative stress and regulating mitochondrial function. Therefore, SIRT1 can improve the ovarian reserve function and prolong ovarian life. SIRT1 can also increase the number of eggs, embryo formation rate and clinical pregnancy rate during assisted reproductive technology (ART). This paper reviews the research progress on SIRT1 in improving ovarian reserve function by inhibiting oocyte senescence.

Key words: Oocytes, Aging, Ovarian reserve, Sirtuins, Reproductive techniques, assisted