Abstract: More and more evidences suggest that early life exposure to environmental endocrine disruptors (EEDs) can cause the change of ovarian structure and function, following adult reproductive dysfunction. Premature ovarian insufficiency (POI) is a heterogeneous disease with complex and diverse etiologies, 75%-90% of which are unknown idiopathic POI. The epigenetic modification and environmental factors have been identified to cause reproductive damage. Human even from embryo is widely exposed to environmental EEDs, and EEDs can have a lifelong impact on female reproduction. In this paper, the four windows of ovarian sensitivity to EEDs(included PGCs sdevelopment, Meiosis, PFs formation，follicles recruitment), and the mechanism of EEDs related to POI were reviewed.

Key words: Primary ovarian insufficiency, Environment;, Endocrine disruptors;, Ovarian follicle;, Ovarian reserve;Meiosis, Oxidative stress