The Pathogenesis of Chronic Endometritis: A Review

doi:10.12280/gjszjk.20220294

Abstract

Abstract:

Chronic endometritis (CE), a persistent endometrial inflammation caused by pathogen infection, is related to adverse pregnancy outcomes. However, there are still disagreement in the diagnosis and treatment of CE. Exploring the inflammatory mechanism of CE is helpful to improve the diagnosis and treatment of CE. The occurrence and development of CE is closely related to the activation of inflammatory pathways, such as TLR and NLR pathways. The metabolic changes of endometrial immune cells, dysregulation of microRNAs and alteration of DNA methylation patterns can abnormally regulate the generation of inflammatory mediators that are related to the pathogenesis and development of CE. The inflammatory mechanism of CE was reviewed in this article, providing a valuable information for understanding in-depth the pathogenesis and pathophysiological changes of CE, and for seeking more standardized and effective diagnostic and treatment measures of CE.

Key words: Endometritis, Signaling transduction, Metabolism, MicroRNAs, DNA methylation

XIONG Yu-jing, LUO Wan-bin, AI Xi-xiong, XU Yan-wen. The Pathogenesis of Chronic Endometritis: A Review[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(1): 60-65.

Figures/Tables 1

References 38

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调控通路	miRNA	所用细胞模型	靶点	功能	参考文献
TLR通路	miR-34a	BEEC	LGR4	促炎	[27]
	miR-643	HEEC	TRAF6	抑炎	[28]
	miR-505	BEEC	HMGB1	抑炎	[29]
	miR-let-7c-5p	BEEC	Ras	抑炎	[30]
	miR-424-5p	BEEC	IRAK2	抑炎	[31]
	miR-218	BEEC	MIP-1	抑炎	[8]
	miR-19a	BEEC	TBK1	抑炎	[32]
	miR-1434-5p	BESC	TBK1、CXCL5、 CXCL8、CXCL9	抑炎	[26]
	miR-200c	BESC	RelA（p65）	抑炎	[33]
	miR-1247-3p	BESC	MAPK11	抑炎	[33]
NLR通路	miR-31	BESC	IL-1β	抑炎	[26]

调控通路	miRNA	所用细胞模型	靶点	功能	参考文献
TLR通路	miR-34a	BEEC	LGR4	促炎	[27]
	miR-643	HEEC	TRAF6	抑炎	[28]
	miR-505	BEEC	HMGB1	抑炎	[29]
	miR-let-7c-5p	BEEC	Ras	抑炎	[30]
	miR-424-5p	BEEC	IRAK2	抑炎	[31]
	miR-218	BEEC	MIP-1	抑炎	[8]
	miR-19a	BEEC	TBK1	抑炎	[32]
	miR-1434-5p	BESC	TBK1、CXCL5、 CXCL8、CXCL9	抑炎	[26]
	miR-200c	BESC	RelA（p65）	抑炎	[33]
	miR-1247-3p	BESC	MAPK11	抑炎	[33]
NLR通路	miR-31	BESC	IL-1β	抑炎	[26]