Research Progress of Stem Cell Therapy for Thin Endometrium

doi:10.12280/gjszjk.20230085

Abstract

Abstract:

Thin endometrium can affect endometrial receptivity, thereby reducing the embryo implantation rate, clinical pregnancy rate and live birth rate of women of childbearing age, which even leads to infertility. There are many treatments for thin endometrium, but the efficacy is not ideal. In recent years, stem cells have attracted more and more attention as a potential cell-based therapy, as a promising cell replacement therapy due to its advantages of lower immunogenicity and higher self-renewal and differentiation ability. Studies have shown that the transplantation of stem cells from different sources, such as menstrual blood, endometrium, bone marrow, adipose tissue and umbilical cord, can effectively promote the recovery of thin endometrium morphology and function. Although stem cells have great potential in the treatment of thin endometrium, there are also some problems such as low transplantation rate, tumor formation possibility, purification and preparation difficulty. This article reviews the clinical trials of stem cells from different sources in thin endometrium.

Key words: Stem cells, Stem cell transplantation, Endometrium, Infertility, female, Pregnancy rate

XIONG Shu-yun, SUN Ke-feng, LI Yu-ke, XU Ying-hong, LIU Ming-hao. Research Progress of Stem Cell Therapy for Thin Endometrium[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(4): 334-338.

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