The Mechanism of Platelet-Rich Plasma on Improving Ovarian Reserve

doi:10.12280/gjszjk.20230087

Abstract

Abstract:

The platelet-rich plasma (PRP) is a concentrate extracted from whole blood centrifugation at a platelet concentration of up to 7 times that of circulating serum, being rich in growth factors and cytokines. Some of factors promote tissue healing and regeneration by inducing chemotaxis, cell migration and differentiation. Ovarian reserve refers to the quality and quantity of eggs retained in ovaries, which is an important indicator of female fertility potential. Based on the current basic research and clinical trials at home and abroad, it is proposed that PRP can promote ovarian vascular production, reduce apoptosis of granule cells and atresia of follicles, promote cumulus dilation, increase mitochondrial activity pathway and promote oocyte development. This review may provide a theoretical basis for the clinical practice of PRP in the assisted reproduction of those women with the reduced ovarian reserve.

Key words: Platelet-rich plasma, Ovarian reserve, Infertility, female, Oocytes

LIU Xu, YANG Ai-jun, LI Ze-wu, SHI Cheng, LIU Li-jun, KONG Xiao-li, WANG Jing-wen. The Mechanism of Platelet-Rich Plasma on Improving Ovarian Reserve[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(4): 329-333.

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