Low-Grade Chronic Inflammation in Polycystic Ovary Syndrome Women

doi:10.12280/gjszjk.20230359

Abstract

Abstract:

Polycystic ovary syndrome (PCOS) is characterized by ovulatory dysfunction, insulin resistance, and hyperandrogenemia, and is one of the main causes of female infertility. Its etiology is complex, and many studies in recent years have shown that its pathogenesis may be related to low-grade chronic inflammation. Systemic low-grade chronic inflammation is often associated with obesity, insulin resistance and hyperandrogenemia. Inflammation in the ovaries can affect follicular development and ovulation. In addition to affecting reproductive function, inflammation also increases the risk of other diseases, such as non-alcoholic fatty liver disease. This article provides a detailed overview of the complex relationship between obesity, insulin resistance, hyperandrogenemia, and inflammation in PCOS patients, and outlines how inflammation is involved in ovulatory disorders and the diseases outside the reproductive system.

Key words: Polycystic ovary syndrome, Inflammation, Obesity, Insulin resistance, Cytokines

QU Hui-ying, GUI Wen-wu. Low-Grade Chronic Inflammation in Polycystic Ovary Syndrome Women[J]. Journal of International Reproductive Health/Family Planning, 2024, 43(1): 48-52.

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