Advances of Endoplasmic Reticulum Stress in Polycystic Ovary Syndrome

doi:10.12280/gjszjk.20230410

Abstract

Abstract:

Polycystic ovary syndrome (PCOS) is a prevalent gynecological endocrine disorder characterized by menstrual disorders, infertility, hirsutism, acne and obesity. The precise pathogenesis of PCOS remains unclear. Recent evidence has demonstrated the involvement of endoplasmic reticulum stress in its pathological process, suggesting the potential of endoplasmic reticulum stress as a novel therapeutic target for PCOS. Endoplasmic reticulum stress refers to the state where the endoplasmic reticulum is in a state of steady imbalance and the accumulation of incorrectly folded or unfolded proteins in the endoplasmic reticulum. Moderate endoplasmic reticulum stress contributes to the development and maturation of follicles. Sustained endoplasmic reticulum stress leads to the abnormal follicle development, hormonal and insulin synthesis and secretion disorders in PCOS patients by inducing granulosa cell apoptosis and mediating processes such as steroid hormone metabolism, glucose metabolism and lipid metabolism, thereby impairing female fertility. This paper provides an overview of the relationship between endoplasmic reticulum stress and various pathogenic factors associated with PCOS, to offer fresh insights into its etiology and treatment.

Key words: Polycystic ovary syndrome, Endoplasmic reticulum stress, Follicular development, Hyperandrogenism, Insulin resistance, Obesity

LI Wen-ya, ZHANG Qiao-li, YANG Xiao-kui. Advances of Endoplasmic Reticulum Stress in Polycystic Ovary Syndrome[J]. Journal of International Reproductive Health/Family Planning, 2024, 43(1): 53-57.

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